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25-Day Metabolite Monitoring Study of ME/CFS Patients

Study Aim

The study will meticulously analyze daily changes in metabolites from blood samples of individuals with ME/CFS over 25 days, to uncover the complex biological processes contributing to the condition and facilitate patient clustering by dynamic changes, thereby addressing the challenge of clinical and biological diversity within the ME/CFS population.


  • Jarred Younger, BA, PhD

  • Christopher Armstrong, PhD

Updates and Potential

  • IRB/Ethics approval completed.

  •  Samples are all collected.

  • Data collection complete and analysis nearly complete.

  • Paper drafting has begun but waiting for more guidance on data analysis workflow.

  • Another 3 months needed until paper submission.


We’re investigating how disruptions in energy metabolism play a role in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). While past studies have found differences in certain substances in the blood of people, there’s no consistent marker found yet. This might be because ME/CFS patients are quite diverse in both their symptoms and biology. 

To tackle this, our study uses a method called repeated-measures design. This helps reduce differences between individuals and makes our findings more reliable, especially for conditions like ME/CFS where there’s a lot of variability. 

We’re collecting blood samples from ME/CFS patients every day for 25 days. By carefully analyzing these samples using this method, we hope to understand better how the body’s chemistry changes over time in ME/CFS. Our aim is to group patients based on these changing patterns rather than just their static traits, which could lead to better ways to understand and treat ME/CFS in the future.


The image depicts a healthcare professional in the process of collecting a blood sample from a patient. The professional is wearing blue gloves and a surgical mask, following proper sanitary protocols to ensure a sterile environment.

  1. Pattern biology that corresponds to patient symptoms over the course of a day in two international cohorts.
  2. Track the biological impact of meals, social tasks, mental tasks and exercise tasks on ME/CFS patients compared to controls.
  3. Cluster patients based on similar biology-symptom dynamics.
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

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