ME/CFS and Long COVID disrupt many body systems. Traditional research looks at one system at a time. That approach doesn’t work.
That’s where Open Medicine Foundation (OMF) comes in. As a nonprofit, we’ve raised $45 million to fund multisystem collaborative research. OMF brings world-renowned scientists together to study, diagnose, treat, and cure complex diseases.
It’s a bold dream. It’s the path that will get you back to a fulfilling life.
Neuroendocrine System: Dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis have been observed, leading to abnormalities in stress response, sex hormone levels, and autonomic nervous system regulation.
Immune System: The immune system is composed of white blood cells, antibodies, and other components. It defends the body against infections and diseases, helping to maintain overall health
Cardiovascular System: The cardiovascular system, comprising the heart, blood vessels, and blood, is responsible for transporting oxygen, nutrients, hormones, and waste products throughout the body. Its efficient functioning ensures the delivery of essential substances and the removal of waste products.
Metabolism: Metabolism involves dysregulation in energy production, particularly in ATP synthesis and mitochondrial function. Abnormalities in carbohydrate, lipid, and amino acid metabolism have also been observed. Understanding these metabolic dysfunctions can lead to symptoms such as fatigue and muscle pain.
Genetics: Genetics may contribute to an individual's susceptibility to multisystem disease, including variations in immune system genes, genes involved in energy metabolism, and genes related to neurotransmitter function.
Multiomics: Multiomics combines various omics technologies such as genomics, transcriptomics, and proteomics. By analyzing multiple layers of biological data, multiomics provide a comprehensive understanding of the molecular mechanisms underlying multisystem diseases.
Diagnostics: Diagnostic studies help identify specific biomarkers, imaging techniques, and diagnostic criteria that aid in distinguishing different diseases within the multisystem spectrum.
Treatments: Treatment studies evaluate the efficacy and safety of potential interventions. By conducting rigorous clinical trials and treatment studies, researchers can refine existing therapies, develop new interventions, and provide evidence-based guidelines for healthcare providers.
Systems biology: Systems biology is an interdisciplinary approach that combines biology, mathematics, and computational analysis. It helps identify key pathways, biomarkers, and potential therapeutic targets, leading to personalized and more effective treatments for multisystem disease patients.
Pathogens: Infections can trigger or exacerbate symptoms, leading to increased fatigue, pain, and cognitive difficulties. Pathogens can also contribute to immune system dysregulation and inflammation.
By funding studies that examine multiple systems, researchers can see how ME/CFS and Long COVID develop. This approach will lead to more effective treatments and improved quality of life.
Click on each system to read a description.
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