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New publication from Dr. David Systrom & Colleagues!

New publication from Dr. David Systrom & Colleagues! 

 “Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-Acute Sequelae of SARS-CoV-2: More in Common Than Not?”

Read it now.
(Full article available as PDF)

OMF is proud to be one of the funders of this important publication!


Topic Importance: Long COVID (Post-Acute Sequelae of SARS-CoV-2, “PASC”) is a debilitating condition that often shares overlapping symptoms with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS), such as extreme fatigue, post-exertional malaise (PEM) and orthostatic intolerance. Scientists don’t fully understand why this happens.

Deconditioning has been suggested as a cause for exercise intolerance in these patients, but the results of Cardiopulmonary Exercise Testing (CPET) argue against it. Instead, issues with blood flow and oxygen use seem to be relevant.


This review aims to highlight the similarities between Long COVID and ME/CFS in terms of exercise-related issues, which could help guide future diagnostics and treatment for both conditions.



Open Medicine Foundation is committed to funding groundbreaking research and publications like this, which has the potential to improve the lives of millions of people suffering from ME/CFS, Long COVID, and related chronic, complex diseases.

Your support is crucial in accelerating research, advancing our understanding of these complex conditions, and ultimately finding effective diagnostics and treatments.

Please consider making a donation today to support our ongoing efforts. Every contribution, big or small, makes a significant impact on the lives of those affected by these debilitating conditions.


Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

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