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Deep Proteome and Metabolome Profiling

Study AIM

Collaborate with OMF CRCs in Uppsala and Melbourne to establish a global perspective.

Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM) through: 

  • Deep phenotyping of ME patients 
  • Global proteomic plasma profiling of ME patients
  • Global metabolomics plasma profiling of ME patients
LEAD INVESTIGATORS
  • Alain Moreau, PhD
  • Jonas Bergquist, MD, PhD
  • Chris Armstrong, PhD
  • Neil McGregor, BDS, MDSc, PhD
Updates and Potential
  • Our preliminary findings indicate that patients with ME/CFS may experience increased red blood cell breakdown after exertion.
  • Specific genotypes of Haptoglobin may be linked to more severe symptoms and worse outcomes after exertion.
  • Global plasma metabolomics have identified molecules that may be associated with more severe post-exertional malaise in people with ME/CFS.
  • Multiple manuscripts are in preparation.
STUDY HYPOTHESIS AND DESCRIPTION

By leveraging our expertise across Open Medicine Foundation ecosystem and through a unique partnership between three OMF Collaborative ME/CFS Research Centers (Melbourne, Montreal and Uppsala), our research team will examine the connections between molecules circulating in the blood and ME. 

This project will provide a more comprehensive understanding as to why some ME patients exhibit different symptoms and how post-exertional malaise exacerbated many symptoms. Identifying specific biomarkers will aid in the development of risk prediction of complications associated with ME, early prevention and better treatments to alleviate the most severe symptoms, which can lead eventually to new therapeutic approaches to cure ME.

No single-omic approach can completely elucidate the multitude of alterations taking place in ME. The DOMINO-ME project will couple a deep phenotyping characterization of ME patients to unbiased discovery strategies by combining global proteomic and metabolomics plasma samples profiling to uncover ME pathogenesis.

Objectives
  1. Collaboration between OMF CRCs in Montreal, Uppsala, and Melbourne to establish a global perspective.
  2. Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms, with a particular emphasis on post-exertional malaise (PEM) through:
    1. Deep phenotyping of ME/CFS patients
    2. Global proteomic plasma profiling of ME/CFS patients
    3. Global metabolomics plasma profiling of ME/CFS patients

Other links you might be interested in:

University of Montreal Collaborative Research Center
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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

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